My husband and I celebrated our 25th anniversary last year and we went to Italy for 2 weeks. It was fabulous. We stayed in an Agritourismo. It is basically a working farm and they have guest houses on the farm for vacation rental. The first week we stayed in Tuscany and the second week we stayed in the mountains of the Emilia-Romagna region. Just fab.
The first week: View from Il Casalone
Their website: http://www.ilcasalone.it/agriturismo.uk.php
The second week: View from Il Corboli
Their website: http://www.agriturismocorboli.it/inglese/idxenglish.htm
We spent most of the time in the car driving through all the wonderful and quaint small villages. We aren't big city museum dwellers so we spent about 4 hours in Rome, 4 hours in Florence, 4 hours in Venice and the rest of the time we spent in the glorious countryside and small villages. Best opportunity for sampling the food. No, we don't speak Italian and they don't speak English in those small villages either but somehow we all found a way to communicate.
Also, if you are a Starbucks patron, don't think about going to Italy and ordering "latte". You had better say "cafe latte" cause otherwise, latte is what you'll get. (Ask me how I know)
The Coliseum in Rome was awesome.
Some other beautiful places will be posted shortly.